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Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.

ABSTRACT: BACKGROUND:We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg?+?mice exhibit impaired function indicative of heart failure. The present study was undertaken to understand the underlying transcriptional alterations in the RV of MuRF1-/- and MuRF1 Tg?+?mice. METHODS:Microarray analysis was performed on RNA isolated from the RV of MuRF1-/-, MuRF1 Tg+, and wild-type control mice exposed to CH. RESULTS:MuRF1-/- RV differentially expressed 590 genes in response to CH. Analysis of the top 66 genes (>?2-fold or??3-fold or?

SUBMITTER: Oakley RH 

PROVIDER: S-EPMC6150973 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.

Oakley Robert H RH   Campen Matthew J MJ   Paffett Michael L ML   Chen Xin X   Wang Zhongjing Z   Parry Traci L TL   Hillhouse Carolyn C   Cidlowski John A JA   Willis Monte S MS  

BMC medical genetics 20180921 1

<h4>Background</h4>We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1-/- mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice exhibit impaired function indicative of heart failure. The present study was undertaken to understand the underlying transcriptional alterations in the RV of MuRF1-/- and MuRF1 Tg + mice.<h4>Methods</h4  ...[more]

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