Ontology highlight
ABSTRACT:
SUBMITTER: El-Sharkawy LY
PROVIDER: S-EPMC7728307 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
El-Sharkawy Lina Y LY Brough David D Freeman Sally S
Molecules (Basel, Switzerland) 20201125 23
Inflammasomes are protein complexes which are important in several inflammatory diseases. Inflammasomes form part of the innate immune system that triggers the activation of inflammatory cytokines interleukin (IL)-1β and IL-18. The inflammasome most studied in sterile inflammation and non-communicable disease is the NLRP3 inflammasome. Upon activation by diverse pathogen or disease associated signals, NLRP3 nucleates the oligomerization of an adaptor protein ASC forming a platform (the inflammas ...[more]