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Synthesis and Properties of Pentafluorosulfanyl Group (SF₅)-Containing Meta-Diamide Insecticides.

ABSTRACT: Herein, we describe novel pentafluorosulfanyl (SF₅) group-containing meta-diamide insecticides. For the facile preparation of the SF₅-based compounds 4a-d, practical synthetic methods were applied. Among newly synthesized compounds, 3-benzamido-N-(2,6-dimethyl-4-(pentafluoro-?⁶-sulfanyl)phenyl)-2-fluorobenzamide 4d showed (i) a high insecticidal activity, (ii) an excellent selectivity to insects, and (iii) good levels of water solubility and log P values. In this study, we demonstrated that the pentafluorosulfanyl moiety could serve as an attractive functionality for the discovery of a new scope of crop-protecting agents.

SUBMITTER: Kim JG

PROVIDER: S-EPMC7728329 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Synthesis and Properties of Pentafluorosulfanyl Group (SF5)-Containing Meta-Diamide Insecticides.

Kim Jae Gon JG Kang On-Yu OY Kim Sang Mee SM Issabayeva Guldana G Oh In Seok IS Lee Yaeji Y Lee Won Hyung WH Lim Hwan Jung HJ Park Seong Jun SJ

Molecules (Basel, Switzerland) 20201125 23

Herein, we describe novel pentafluorosulfanyl (SF5) group-containing meta-diamide insecticides. For the facile preparation of the SF5-based compounds 4a-d, practical synthetic methods were applied. Among newly synthesized compounds, 3-benzamido-N-(2,6-dimethyl-4-(pentafluoro-λ6-sulfanyl)phenyl)-2-fluorobenzamide 4d showed (i) a high insecticidal activity, (ii) an excellent selectivity to insects, and (iii) good levels of water solubili ...[more]

PMID: 33255851

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