Ontology highlight
ABSTRACT:
SUBMITTER: Pal A
PROVIDER: S-EPMC7728445 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
eLife 20201130
Wnt signaling is downregulated in embryonal rhabdomyosarcoma (ERMS) and contributes to the block of differentiation. Epigenetic mechanisms leading to its suppression are unknown and could pave the way toward novel therapeutic modalities. We demonstrate that EHMT2 suppresses canonical Wnt signaling by activating expression of the Wnt antagonist <i>DKK1</i>. Inhibition of EHMT2 expression or activity in human ERMS cell lines reduced <i>DKK1</i> expression and elevated canonical Wnt signaling resul ...[more]