Ontology highlight
ABSTRACT:
SUBMITTER: Gray JI
PROVIDER: S-EPMC7730012 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Gray Joshua I JI Al-Khabouri Shaima S Morton Fraser F Clambey Eric T ET Gapin Laurent L Matsuda Jennifer L JL Kappler John W JW Marrack Philippa P Garside Paul P Otto Thomas D TD MacLeod Megan K L MKL
Immunology 20201027 1
Memory T cells respond rapidly in part because they are less reliant on a heightened levels of costimulatory molecules. This enables rapid control of secondary infecting pathogens but presents challenges to efforts to control or silence memory CD4 T cells, for example in antigen-specific tolerance strategies for autoimmunity. We have examined the transcriptional and functional consequences of reactivating memory CD4 T cells in the absence of an adjuvant. We find that memory CD4 T cells generated ...[more]