Ontology highlight
ABSTRACT:
SUBMITTER: Wang MS
PROVIDER: S-EPMC7730554 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20201201 23
A robust, practical, and scalable approach for the construction of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives <b>13</b> via the addition of Grignard reagents to 4-amino-2-chloronicotinonitrile (<b>15</b>) was developed. Starting with various Grignard reagents, a wide range of 3-substituted 5-chloro-1,6-naphthyridin-4-one derivatives <b>13</b> were conveniently synthesized in moderate-to-good yields through addition-acidolysis-cyclocondensation. In addition, the robustness and appl ...[more]