Ontology highlight
ABSTRACT:
SUBMITTER: Lopez X
PROVIDER: S-EPMC7731223 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
López Ximena X Escamilla Rosalba R Fernández Paola P Duarte Yorley Y González-Nilo Fernando F Palacios-Prado Nicolás N Martinez Agustín D AD Sáez Juan C JC
International journal of molecular sciences 20201202 23
Pannexin 1 channels located in the cell membrane are permeable to ions, metabolites, and signaling molecules. While the activity of these channels is known to be modulated by phosphorylation on T198, T308, and S206, the possible involvement of other putative phosphorylation sites remains unknown. Here, we describe that the activity of Panx1 channels induced by mechanical stretch is reduced by adenosine via a PKA-dependent pathway. The mechanical stretch-induced activity-measured by changes in DA ...[more]