Ontology highlight
ABSTRACT:
SUBMITTER: Wouters E
PROVIDER: S-EPMC7731422 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Wouters Elien E Grajchen Elien E Jorissen Winde W Dierckx Tess T Wetzels Suzan S Loix Melanie M Tulleners Marie Paule MP Staels Bart B Stinissen Piet P Haidar Mansour M Bogie Jeroen F J JFJ Hendriks Jerome J A JJA
International journal of molecular sciences 20201207 23
Macrophages play a crucial role during the pathogenesis of multiple sclerosis (MS), a neuroinflammatory autoimmune disorder of the central nervous system. Important regulators of the metabolic and inflammatory phenotype of macrophages are liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs). Previously, it has been reported that PPARγ expression is decreased in peripheral blood mononuclear cells of MS patients. The goal of the present study was to determine to what ex ...[more]