Dataset Information

Case of Lead Poisoning Associated with Herbal Health Supplements.

ABSTRACT:

Background

Lead poisoning is a chronic health condition arising from prolonged ingestion and exposure to lead above permissible limits. Although reported globally, developing countries like India and neighboring countries are amongst the most affected by lead.

Objectives

The aim of the present study was to evaluate lead poisoning associated with herbal health supplements in a suspected case.

Materials and methods

A 31-year-old male reported consuming sixteen different herbal health supplements. The case and supplements were assessed for lead levels. The patient came from one of the metro cities of Uttar Pradesh state, India.

Results

The blood lead level of the case was found to be 78.40 ?g/dL, which was much higher than the permissible limit of ?5 ?g/dL. Moreover, one of the supplements was found to have a very high lead content.

Conclusions

The present study demonstrated a case of lead poisoning which was very likely due to high lead content present in one of the supplements. The case had typical neurological signs of lead toxicity such as irritability, frequent headache, mental dullness, generalized pain, muscle weakness, numbness and tingling, and twitching and shaking of the legs while sleeping.

Patient consent

Obtained.

Competing interests

The authors declare no competing financial interests.

SUBMITTER: Mahdi AA

PROVIDER: S-EPMC7731492 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Publications

Case of Lead Poisoning Associated with Herbal Health Supplements.

Mahdi Abbas Ali AA Ansari Jamal Akhtar JA Agarwal Avinash A Ahmad M Kaleem MK Siddiqui Suhail Sarwar SS Jafar Tabrez T Venkatesh Thuppil T

Journal of health & pollution 20201207 28

<h4>Background</h4>Lead poisoning is a chronic health condition arising from prolonged ingestion and exposure to lead above permissible limits. Although reported globally, developing countries like India and neighboring countries are amongst the most affected by lead.<h4>Objectives</h4>The aim of the present study was to evaluate lead poisoning associated with herbal health supplements in a suspected case.<h4>Materials and methods</h4>A 31-year-old male reported consuming sixteen different herba ...[more]

PMID: 33324511

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Project description:BackgroundDNA-based testing has been gaining acceptance as a tool for authentication of a wide range of food products; however, its applicability for testing of herbal supplements remains contentious.MethodsWe utilized Sanger and Next-Generation Sequencing (NGS) for taxonomic authentication of fifteen herbal supplements representing three different producers from five medicinal plants: Echinacea purpurea, Valeriana officinalis, Ginkgo biloba, Hypericum perforatum and Trigonella foenum-graecum. Experimental design included three modifications of DNA extraction, two lysate dilutions, Internal Amplification Control, and multiple negative controls to exclude background contamination. Ginkgo supplements were also analyzed using HPLC-MS for the presence of active medicinal components.ResultsAll supplements yielded DNA from multiple species, rendering Sanger sequencing results for rbcL and ITS2 regions either uninterpretable or non-reproducible between the experimental replicates. Overall, DNA from the manufacturer-listed medicinal plants was successfully detected in seven out of eight dry herb form supplements; however, low or poor DNA recovery due to degradation was observed in most plant extracts (none detected by Sanger; three out of seven-by NGS). NGS also revealed a diverse community of fungi, known to be associated with live plant material and/or the fermentation process used in the production of plant extracts. HPLC-MS testing demonstrated that Ginkgo supplements with degraded DNA contained ten key medicinal components.ConclusionQuality control of herbal supplements should utilize a synergetic approach targeting both DNA and bioactive components, especially for standardized extracts with degraded DNA. The NGS workflow developed in this study enables reliable detection of plant and fungal DNA and can be utilized by manufacturers for quality assurance of raw plant materials, contamination control during the production process, and the final product. Interpretation of results should involve an interdisciplinary approach taking into account the processes involved in production of herbal supplements, as well as biocomplexity of plant-plant and plant-fungal biological interactions.

Dataset Information

Case of Lead Poisoning Associated with Herbal Health Supplements.

Background

Objectives

Materials and methods

Results

Conclusions

Patient consent

Competing interests

Publications

Case of Lead Poisoning Associated with Herbal Health Supplements.

Similar Datasets

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