Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes.

ABSTRACT:

Background

As hospital sepsis mortality has decreased, more surgical ICU survivors are progressing into chronic critical illness (CCI). This study documents the incidence of CCI and long-term outcomes of patients with abdominal sepsis. We hypothesized that patients developing CCI would have biomarker evidence of immune and metabolic derangement, with a high incidence of poor 1-year outcomes.

Methods

Review of abdominal sepsis patients entered in a prospective longitudinal study of surgical ICU sepsis.

Results

Of the 144 study patients, only 6% died early, 37% developed CCI (defined as ICU days ≥14 with organ dysfunction) and 57% were classified rapid recovery (RAP). Compared to RAP, CCI patients a) were older (66 vs 58), males who were sicker at baseline (Charlson Com

SUBMITTER: Cox MC 

PROVIDER: S-EPMC7731616 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature