Ontology highlight
ABSTRACT:
SUBMITTER: Heydarkhan-Hagvall S
PROVIDER: S-EPMC7731733 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Biomaterials 20111212 7
While stem cell niches in vivo are complex three-dimensional (3D) microenvironments, the relationship between the dimensionality of the niche to its function is unknown. We have created a 3D microenvironment through electrospinning to study the impact of geometry and different extracellular proteins on the development of cardiac progenitor cells (Flk-1(+)) from resident stem cells and their differentiation into functional cardiovascular cells. We have investigated the effect of collagen IV, fibr ...[more]