Ontology highlight
ABSTRACT:
SUBMITTER: Peterle D
PROVIDER: S-EPMC7733459 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Communications biology 20201211 1
Aggregation of human wild-type transthyretin (hTTR), a homo-tetrameric plasma protein, leads to acquired senile systemic amyloidosis (SSA), recently recognised as a major cause of cardiomyopathies in 1-3% older adults. Fragmented hTTR is the standard composition of amyloid deposits in SSA, but the protease(s) responsible for amyloidogenic fragments generation in vivo is(are) still elusive. Here, we show that subtilisin secreted from Bacillus subtilis, a gut microbiota commensal bacterium, transl ...[more]