Ontology highlight
ABSTRACT:
SUBMITTER: Qazi S
PROVIDER: S-EPMC7734702 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Qazi Shefah S Miettinen Heini M HM Wilkinson Royce A RA McCoy Kimberly K Douglas Trevor T Wiedenheft Blake B
Molecular pharmaceutics 20160222 3
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNA-guided endonucleases are powerful new tools for targeted genome engineering. These nucleases provide an efficient and precise method for manipulating eukaryotic genomes; however, delivery of these reagents to specific cell-types remains challenging. Virus-like particles (VLPs) derived from bacteriophage P22, are robust supramolecular protein cage structures with demonstrated utility for cell type-specific delivery of encapsul ...[more]