Ontology highlight
ABSTRACT:
SUBMITTER: Kim G
PROVIDER: S-EPMC7736125 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kim Garam G Gautier Olivia O Tassoni-Tsuchida Eduardo E Ma X Rosa XR Gitler Aaron D AD
Neuron 20200914 5
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss of motor neurons from the brain and spinal cord. The ALS community has made remarkable strides over three decades by identifying novel familial mutations, generating animal models, elucidating molecular mechanisms, and ultimately developing promising new therapeutic approaches. Some of these approaches reduce the expression of mutant genes and are in human clinical trials, highlighting the need to carefu ...[more]