The bivariate NRIP1/ZEB2 RNA marker permits non-invasive presymptomatic screening of pre-eclampsia.
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ABSTRACT:
SUBMITTER: Manders V
PROVIDER: S-EPMC7736279 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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The bivariate NRIP1/ZEB2 RNA marker permits non-invasive presymptomatic screening of pre-eclampsia.
Manders Vera V Visser Allerdien A Keijser Remco R Min Naomi N Poutsma Ankie A Mulders Joyce J van den Berkmortel Tarah T Hortensius Marjolein M Jongejan Aldo A Pajkrt Eva E Sistermans Erik A EA Sie Daoud D Best Myron G MG Würdinger Tom T de Boer Marjon M Afink Gijs G Oudejans Cees C
Scientific reports 20201214 1
Using genome-wide transcriptome analysis by RNA sequencing of first trimester plasma RNA, we tested whether the identification of pregnancies at risk of developing pre-eclampsia with or without preterm birth or growth restriction is possible between weeks 9-14, prior to the appearance of clinical symptoms. We implemented a metaheuristic approach in the self-learning SVM algorithm for differential gene expression analysis of normal pregnancies (n = 108), affected pregnancies (n = 34) and non-preg ...[more]
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