Ontology highlight
ABSTRACT:
SUBMITTER: Sweiss K
PROVIDER: S-EPMC7741423 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Sweiss Karen K Calip Gregory S GS Johnson Jeremy J JJ Rondelli Damiano D Patel Pritesh R PR
Bone marrow transplantation 20190806 12
Melphalan is given at a dose of 200 mg/m<sup>2</sup> (Mel200) prior to ASCT for multiple myeloma (MM). Pharmacokinetic (PK) studies show a high degree of interpatient variability. We aimed to test the impact of clinical factors previously shown to affect melphalan PK such as hemoglobin (Hgb), fat-free mass (FFM), and creatinine clearance (CrCl) on outcomes. Median Hgb (from day -2 to -1) and FFM were grouped as low or high relative to their sample medians, and CrCl was divided into ≥60 or <60 ml ...[more]