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Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients.


ABSTRACT: We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured using automated brain volumetry (NeuroQuant). The Unified Parkinson Disease Rating Scale motor score quotient was used to assess changes in clinical outcome and compare the preoperative regional brain volume in patients categorized into the higher motor improvement and lower motor improvement groups based on changes in the postoperative scores. The study groups showed significant volume differences in multiple brain areas. In the higher motor improvement group, the anterior cingulate and right thalamus showed high volumes after false discovery rate (FDR) correction. In the lower motor improvement group, the left caudate, paracentral, right primary sensory and left primary motor cortex showed high volume, but no area showed high volumes after FDR correction. Our data suggest that the effectiveness of DBS in patients with PD may be affected by decreased brain volume in different areas, including the cingulate gyrus and thalamus. Preoperative volumetry could help predict outcomes in patients with PD undergoing DBS.

SUBMITTER: Yim Y 

PROVIDER: S-EPMC7744532 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Pretreatment brain volumes can affect the effectiveness of deep brain stimulation in Parkinson's disease patients.

Yim Younghee Y   Kim Sang Joon SJ   Jung Seung Chai SC   Kim Ho Sung HS   Choi Choong Gon CG   Lee Jung Kyo JK   Lee Chong Sik CS   Lee Seung Hyun SH   Shim Woo Hyun WH   Cheong E-N EN   Park Seong-Cheol SC  

Scientific reports 20201216 1


We aimed to assess whether brain volumes may affect the results of deep brain stimulation (DBS) in patients with Parkinson's disease (PD). Eighty-one consecutive patients with PD (male:female 40:41), treated with DBS between June 2012 and December 2017, were enrolled. Total and regional brain volumes were measured using automated brain volumetry (NeuroQuant). The Unified Parkinson Disease Rating Scale motor score quotient was used to assess changes in clinical outcome and compare the preoperativ  ...[more]

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