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Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice.

ABSTRACT: The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection.

SUBMITTER: Kuwentrai C

PROVIDER: S-EPMC7744900 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice.

Kuwentrai Chaiyaporn C Yu Jinming J Rong Li L Zhang Bao-Zhong BZ Hu Ye-Fan YF Gong Hua-Rui HR Dou Ying Y Deng Jian J Huang Jian-Dong JD Xu Chenjie C

Bioengineering & translational medicine 20201212 1

The S1 subunit of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein contains an immunogenic receptor-binding domain (RBD), which is a promising candidate for the development of a potential vaccine. This study demonstrated that intradermal delivery of an S-RBD vaccine using a dissolvable microneedle skin patch can induce both significant B-cell and significant T-cell responses against S-RBD. Importantly, the outcomes were comparable to that of conventional bolus injection ...[more]

PMID: 33349797

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