Dataset Information

Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.

ABSTRACT:

Setting

Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes.

Objective

To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.

Design

Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and being at-risk for alcohol use disorders (AUD) were assessed using the AUDIT-C. Univariable and multivariable analyses were conducted.

Results

Of 1166 PLWTB, 691 (59.3%) were drinkers; of those, 518/691 (75.0%) were at-risk for AUD. Drinkers had more lung affected than non-drinkers (adjusted mean difference 10.8%, p<0.0001); this was not significant for those at-risk for AUD (adjusted mean difference 3.7%, p = 0.11). High smear grade (aOR 1.0, 95%CI: 0.7-1.4), cavitation (aOR 0.8, 95%CI 0.4-1.8), and TTP (mean difference 5.2 hours, p = 0.51) did not differ between drinkers and non-drinkers, nor between those at-risk and not at-risk for AUD.

Conclusions

A large proportion of PLWTB were drinkers and were at-risk for AUD. Alcohol drinkers had more lung affected than non-drinkers. Studies are needed to explore mechanisms of this association.

SUBMITTER: Kan CK

PROVIDER: S-EPMC7746146 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.

Kan Carolyn K CK Ragan Elizabeth J EJ Sarkar Sonali S Knudsen Selby S Forsyth Megan M Muthuraj Muthaiah M Vinod Kumar K Jenkins Helen E HE Horsburgh C Robert CR Salgame Padmini P Roy Gautam G Ellner Jerrold J JJ Jacobson Karen R KR Sahu Swaroop S Hochberg Natasha S NS

PloS one 20201217 12

<h4>Setting</h4>Alcohol use increases the risk of tuberculosis (TB) disease and is associated with worse outcomes.<h4>Objective</h4>To determine whether alcohol use affects TB severity at diagnosis in a high-burden setting.<h4>Design</h4>Participants were smear-positive people living with TB (PLWTB) in India. Disease severity was assessed as 1) high versus low smear grade, 2) time to positivity (TTP) on liquid culture, 3) chest radiograph cavitation, and 4) percent lung affected. Alcohol use and ...[more]

PMID: 33332367

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Dataset Information

Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.

Setting

Objective

Design

Results

Conclusions

Publications

Alcohol use and tuberculosis clinical presentation at the time of diagnosis in Puducherry and Tamil Nadu, India.

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