Dataset Information

Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study.

ABSTRACT:

Background

The aetiology of Parkinson's disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior.

Methods

We carried out a case-control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds ratios (ORs) for PD and 95% confidence intervals (CIs) were estimated with logistic regression, adjusting for actual and potential confounders.

Results

A lower OR was observed in females (0.74; 95%CI:0.58-0.96), while older age classes showed a constantly increased risk for PD (p<0.005) starting from the class 65-69 years. Subjects who reported a first degree relative affected by PD showed a borderline increase which was more evident in those enrolled in the urban center of Rome (OR = 1.65; 95%CI: 1.09-2.50). Significant reduction of the risk was associated to current smoking (OR = 0.48; 95%CI: 0.24-0.54), and to vegetables consumption (p<0.03), while borderline increases were associated to meat and cold cut consumption. Occupational activities classified according to ISCO-08 categories did not show increased risk, while higher ORs' were found for pilots and physicians.

Conclusions

The results from this study confirmed the higher risk of PD in males and in elderly, and the inverse association with smoking habit. The possible etiological role of familial clustering, dietary habit, and some job tasks is suggested.

SUBMITTER: Torti M

PROVIDER: S-EPMC7746265 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study.

Torti Margherita M Fossati Chiara C Casali Miriam M De Pandis Maria Francesca MF Grassini Paola P Radicati Fabiana Giada FG Stirpe Paola P Vacca Laura L Iavicoli Ivo I Leso Veruscka V Ceppi Marcello M Bruzzone Marco M Bonassi Stefano S Stocchi Fabrizio F

PloS one 20201217 12

<h4>Background</h4>The aetiology of Parkinson's disease (PD) is still very controversial, with a peculiar lack of established risk factors or protective behavior.<h4>Methods</h4>We carried out a case-control study of 634 idiopathic PD patients admitted from 2011 to 2015 to two hospitals located in central Italy and 532 controls matched by hospital, gender and age (± 5 years). The study questionnaire included questions on host factors, family history, residence, occupation and lifestyle. Odds rat ...[more]

PMID: 33332388

Similar Datasets

Project description:The role of occupation in the etiology of renal cell carcinoma (RCC) is unclear. Here, we investigated associations between employment in specific occupations and industries and RCC, and its most common histologic subtype, clear cell RCC (ccRCC).Between 2002 and 2007, a population-based case-control study of Caucasians and African Americans (1,217 cases; 1,235 controls) was conducted within the Detroit and Chicago metropolitan areas to investigate risk factors for RCC. As part of this study, occupational histories were ascertained through in-person interviews. We computed odds ratios (ORs) and 95% confidence intervals (CIs) relating occupation and industry to RCC risk using adjusted unconditional logistic regression models.Employment in the agricultural crop production industry for five years or more was associated with RCC (OR?=?3.3 [95% CI?=?1.0-11.5]) and ccRCC in particular (OR?=?6.3 [95% CI?=?1.7-23.3], P for trend with duration of employment?=?0.0050). Similarly, RCC risk was elevated for employment of five years or longer in non-managerial agricultural and related occupations (ORRCC?=?2.1 [95% CI?=?1.0-4.5]; ORccRCC?=?3.1 [95% CI?=?1.4-6.8]). Employment in the dry-cleaning industry was also associated with elevated risk (ORRCC?=?2.0 [95% CI?=?0.9-4.4], P for trend?=?0.093; ORccRCC?=?3.0 [95% CI?=?1.2-7.4], P for trend?=?0.031). Suggestive elevated associations were observed for police/public safety workers, health care workers and technicians, and employment in the electronics, auto repair, and cleaning/janitorial services industries; protective associations were suggested for many white-collar jobs including computer science and administrative occupations as well employment in the business, legislative, and education industries.Our findings provide support for an elevated risk of RCC in the agricultural and dry-cleaning industries and suggest that these associations may be stronger for the ccRCC subtype. Additional studies are needed to confirm these findings.

Dataset Information

Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study.

Background

Methods

Results

Conclusions

Publications

Effect of family history, occupation and diet on the risk of Parkinson disease: A case-control study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets