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Column versus batch methods for measuring PFOS and PFOA sorption to geomedia.

ABSTRACT: The objective of this study is to compare the consistency between column and batch experiment methods for measuring solid-phase sorption coefficients and isotherms for per and polyfluoroalkyl substances (PFAS). Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are used as representative PFAS, and experiments are conducted with three natural porous media with differing geochemical properties. Column-derived sorption isotherms are generated by conducting multiple experiments with different input concentrations (multi-C₀ method) or employing elution-front integration wherein the entire isotherm is determined from a single breakthrough curve (BTC) elution front. The isotherms generated with the multi-C₀ column method compared remarkably well to the batch isotherms over an aqueous concentration range of 3-4 orders of magnitude. Specifically, the 95% confidence intervals for the individual isotherm variables overlapped, producing statistically identical regressions. The elution-front integration isotherms generally agreed with the batch isotherms, but exhibited noise and systematic deviation at lower concentrations in some cases. All data sets were well described by the Freundlich isotherm model. Freundlich N values ranged from 0.75 to 0.81 for PFOS and was 0.87 for PFOA and are consistent with values reported in the literature for different geomedia. The results of this study indicate that column and batch experiments can measure consistent sorption isotherms and sorption coefficients for PFOS and PFOA when robust experimental setup and data analysis are implemented.

SUBMITTER: Van Glubt S

PROVIDER: S-EPMC7746577 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Adsorption of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) from water using leaf biomass (<i>Vitis vinifera</i>) in a fixed-bed column study.

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Sorption and desorption kinetics of PFOS to pristine microplastic.

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| S-EPMC8741692 | biostudies-literature

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| S-EPMC7785559 | biostudies-literature

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Project description:Perfluoroalkyl acid carboxylates and sulfonates (PFAA) have many consumer and industrial applications. Developmental toxicity studies in animals have raised concern about potential reproductive/developmental effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS); however, in humans conflicting results have been reported for associations between maternal PFAA levels and these outcomes. Risk assessments and interpretation of available human data during gestation and lactation are hindered due to lack of a framework for understanding and estimating maternal, fetal, and neonatal pharmacokinetics (PK). Physiologically based pharmacokinetic (PBPK) models were developed for PFOA and PFOS for the gestation and lactation life stages in humans to understand how the physiological changes associated with development affect pharmacokinetics of these compounds in the mother, fetus, and infant. These models were derived from PBPK models for PFOA/PFOS that were previously developed for adult humans and rats during gestation and lactation and from existing human pregnancy and lactation models developed for other chemicals. The models simulated PFOA and PFOS concentrations in fetal, infant, and maternal plasma and milk, were compared to available data in humans, and also were used to estimate maternal exposure. The models reported here identified several research needs, which include (1) the identification of transporters involved in renal resorption to explain the multiyear half-lives of these compounds in humans, (2) factors affecting clearance of PFOA/PFOS during gestation and lactation, and (3) data to estimate clearance of PFOA/PFOS in infants. These models may help address concerns regarding possible adverse health effects due to PFOA/PFOS exposure in the fetus and infant and may be useful in comparing pharmacokinetics across life stages.

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Toxicity Effects of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) on Two Green Microalgae Species.

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Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements.

Project description:A total of 256 men were studied to evaluate whether serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) impacted semen quality or reproductive hormones. Blood and semen were collected and analyzed for perfluorochemicals and reproductive and thyroid hormones. Semen quality was assessed using standard clinical methods. Linear and logistic modeling was performed with semen profile measurements as outcomes and PFOS and PFOA in semen and plasma as explanatory variables. Adjusting for age, abstinence, and tobacco use, there was no indication that PFOA or PFOS was significantly associated with volume, sperm concentration, percent motility, swim-up motility and concentration, and directional motility (a function of motility and modal progression). Follicle-stimulating hormone was not associated with either PFOA or PFOS. Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms.

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Rapid removal of PFOA and PFOS via modified industrial solid waste: Mechanisms and influences of water matrices.

Project description:Emerging perfluoroalkyl and polyfluoroalkyl substances contaminate waters at trace concentrations, thus rapid and selective adsorbents are pivotal to mitigate the consequent energy-intensive and time-consuming issues in remediation. In this study, coal combustion residuals-fly ash was modified (FA-SCA) to overcome the universal trade-off between high adsorption capacity and fast kinetics. FA-SCA presented rapid adsorption (teq = 2 min) of PFOX (perfluorooctanoic acid and perfluorooctanesulfonic acid, collectively), where the dynamic adsorption capacity (qdyn = qm/teq) was 2-3 orders of magnitude higher than that of benchmark activated carbons and anion-exchange resins. Investigated by advanced characterization and kinetic models, the fast kinetics and superior qdyn are attributed to (1) elevated external diffusion driven by the submicron particle size; (2) enhanced intraparticle diffusion caused by the developed mesoporous structure (Vmeso/Vmicro = 8.1); (3) numerous quaternary ammonium anion-exchange sites (840 μmol/g), and (4) appropriate adsorption affinity (0.031 L/μmol for PFOS, and 0.023 L/μmol for PFOA). Since the adsorption was proven to be a synergistic process of electrostatic and hydrophobic interactions, effective adsorption ([PFOX]ini = 1.21 μM, concentration levels of highly-contaminant-sites) was obtained at conventional natural water chemistries. High selectivity (>85.4% removal) was also achieved with organic/inorganic competitors, especially compounds with partly similar molecular structures to PFOX. In addition, >90% PFOX was removed consistently during five cycles in mild regeneration conditions (pH 12 and 50 °C). Overall, FA-SCA showed no leaching issues of toxic metals and exhibits great potential in both single-adsorption processes and treatment train systems.

| S-EPMC9733903 | biostudies-literature

Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum.

Project description:To determine demographic, reproductive, and maternal dietary factors that predict perfluoroalkyl substance (PFAS) concentrations in breast milk, we measured perfluorooctane sulfonic (PFOS) and perfluorooctanoic acid (PFOA) concentrations, using liquid chromatography-mass spectrometry, in 184 colostrum samples collected from women participating in a cohort study in Eastern Slovakia between 2002 and 2004. During their hospital delivery stay, mothers completed a food frequency questionnaire, and demographic and reproductive data were also collected. PFOS and PFOA predictors were identified by optimizing multiple linear regression models using Akaike's information criterion (AIC). The geometric mean concentration in colostrum was 35.3 pg/mL for PFOS and 32.8 pg/mL for PFOA. In multivariable models, parous women had 40% lower PFOS (95% CI: -56 to -17%) and 40% lower PFOA (95% CI: -54 to -23%) concentrations compared with nulliparous women. Moreover, fresh/frozen fish consumption, longer birth intervals, and Slovak ethnicity were associated with higher PFOS and PFOA concentrations in colostrum. These results will help guide the design of future epidemiologic studies examining milk PFAS concentrations in relation to health end points in children.

| S-EPMC5256678 | biostudies-literature

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