Estrogen receptor ? polymorphism is associated with dementia in a Brazilian cohort.

ABSTRACT: The growth of the elderly population is a worldwide phenomenon and it is associated with chronic diseases, including dementia. In this scenario, the present study aimed to evaluate a possible association of estrogen receptor ? polymorphisms with dementia in a Brazilian cohort. The subject sample was divided into two groups, control (n = 105) and case (n = 73), according to analysis of two predictive dementia tests (MMSE and CDR). The genotyping for the ER? PvuII (c.454-397T>C, rs2234693) and XbaI (c.454-351A>G, rs9340799) polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism. The ER? PvuII pp genotype was associated with higher odds ratio for dementia (OR = 3.42, 95% CI = 1.33-8.77, p = 0.01, in a model including covariates. A linear regression model identified significant associations of the ER? PvuII genotypes (independent variable) with CDR scale (dependent variable), ? = 0.26 and p = 0.001. In conclusion, estrogen receptor ? PvuII polymorphism is associated with dementia in a Brazilian cohort. This finding may be useful for the identification of a possible set of significant genetic and clinical biomarkers for better understanding pathophysiology, early diagnosis and management of dementia.

SUBMITTER: Magnago RPL 

PROVIDER: S-EPMC7747857 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature