Ontology highlight
ABSTRACT:
SUBMITTER: Tamada H
PROVIDER: S-EPMC7748412 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Tamada Hiromi H Blanc Jerome J Korogod Natalya N Petersen Carl Ch CC Knott Graham W GW
eLife 20201204
Previously, we showed that cryo fixation of adult mouse brain tissue gave a truer representation of brain ultrastructure in comparison with a standard chemical fixation method (Korogod et al., 2015). Extracellular space matched physiological measurements, there were larger numbers of docked vesicles and less glial coverage of synapses and blood capillaries. Here, using the same preservation approaches, we compared the morphology of dendritic spines. We show that the length of the spine and the v ...[more]