Ontology highlight
ABSTRACT:
SUBMITTER: Otieno SB
PROVIDER: S-EPMC7748897 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Otieno Steve Biko SB Nasir Syed S Weir Alva A Johnson Robert R
Case reports in hematology 20201211
Patients with relapsed and refractory multiple myeloma have a poor prognosis. The mitogen-activated protein kinase (MAPK) pathway has been implicated in the pathogenesis of multiple myeloma. Several mutations in this pathway can lead to its constitutive activation leading to oncogenesis. One such mutation is BRAFV600E which is a therapeutic target in the treatment of melanoma, lung cancer, colon cancer, thyroid cancer, and hairy cell leukemia. BRAFV600E-directed therapy currently does not have a ...[more]