Ontology highlight
ABSTRACT:
SUBMITTER: Armanious D
PROVIDER: S-EPMC7749048 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Armanious David D Schuster Jessica J Tollefson George A GA Agudelo Anthony A DeWan Andrew T AT Istrail Sorin S Padbury James J Uzun Alper A
Genomics 20200720 6
We posit the likely architecture of complex diseases is that subgroups of patients share variants in genes in specific networks which are sufficient to give rise to a shared phenotype. We developed Proteinarium, a multi-sample protein-protein interaction (PPI) tool, to identify clusters of patients with shared gene networks. Proteinarium converts user defined seed genes to protein symbols and maps them onto the STRING interactome. A PPI network is built for each sample using Dijkstra's algorithm ...[more]