Ontology highlight
ABSTRACT:
SUBMITTER: Yadav B
PROVIDER: S-EPMC7750734 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Yadav Bhawna B Mora-Montes Héctor M HM Wagener Jeanette J Cunningham Iain I West Lara L Haynes Ken K Brown Alistair J P AJP Gow Neil A R NAR
Cell surface (Amsterdam, Netherlands) 20200721
We designed experiments to assess whether fungal cell wall mannans function as an immune shield or an immune agonist. Fungal cell wall β-(1,3)-glucan normally plays a major and dominant role in immune activation. The outer mannan layer has been variously described as an immune shield, because it has the potential to mask the underlying β-(1,3)-glucan, or an immune activator, as it also has the potential to engage with a wide range of mannose detecting PRRs. To resolve this conundrum we examined ...[more]