Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7751893 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Publications
Intercellular Receptor-Ligand Binding and Thermal Fluctuations Facilitate Receptor Aggregation in Adhering Membranes.
Li Long L Hu Jinglei J Różycki Bartosz B Song Fan F
Nano letters 20191224 1
Nanoscale molecular clusters in cell membranes can serve as platforms to recruit membrane proteins for various biological functions. A central question is how these nanoclusters respond to physical contacts between cells. Using a statistical mechanics model and Monte Carlo simulations, we explore how the adhesion of cell membranes affects the stability and coalescence of clusters enriched in receptor proteins. Our results show that intercellular receptor-ligand binding and membrane shape fluctua ...[more]
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