Ontology highlight
ABSTRACT:
SUBMITTER: Sepehri Rad M
PROVIDER: S-EPMC5932030 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Sepehri Rad Masoud M Cohen Lawrence B LB Braubach Oliver O Baker Bradley J BJ
Scientific reports 20180502 1
In eukaryotic cells, the endoplasmic reticulum (ER) is the largest continuous membrane-enclosed network which surrounds a single lumen. Using a new genetically encoded voltage indicator (GEVI), we applied the patch clamp technique to cultured HEK293 cells and neurons and found that there is a very fast electrical interaction between the plasma membrane and internal membrane(s). This discovery suggests a novel mechanism for interaction between the external membrane and internal membranes as well ...[more]