Dataset Information

Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance.

ABSTRACT: Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative diseases. The device and auxiliary software constitute a non-invasive neuromodulation system. The technical problems related to the multichannel high-precision output of the device were solved by an analog phase accumulator and a special driving circuit to reduce crosstalk. The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness. Finite element simulation and phantom measurements were performed to find the functional relations among the target coordinates, current ratio, and electrode position in the simplified model. Then, an appropriate approach was proposed to find electrode configurations for desired target locations in a detailed and realistic mouse model. A mouse validation experiment was carried out under the guidance of a simulation, and the reliability and positioning accuracy of temporally interfering electric stimulators were verified. Stimulator improvement and precision positioning solutions promise opportunities for further studies of temporally interfering electrical stimulation.

SUBMITTER: Wang H

PROVIDER: S-EPMC7753039 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance.

Wang Heng H Shi Zhongyan Z Sun Weiqian W Zhang Jianxu J Wang Jing J Shi Yue Y Yang Ruoshui R Li Chunlin C Chen Duanduan D Wu Jinglong J Gongyao Guo G Xu Yifei Y

Frontiers in neuroinformatics 20201208

Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative disea ...[more]

PMID: 33363461

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Project description:Although precise point positioning (PPP) is a well-established and promising technique with the use of precise satellite orbit and clock products, it costs a long convergence time to reach a centimeter-level positioning accuracy. The PPP with ambiguity resolution (PPP-AR) technique can improve convergence performance by resolving ambiguities after separating the fractional cycle bias (FCB). Now the FCB estimation is mainly realized by the regional or global operating reference station network. However, it does not work well in the areas where network resources are scarce. The contribution of this paper is to realize an ambiguity residual constraint-based PPP with partial ambiguity resolution (PPP-PARC) under no real-time network corrections to speed up the convergence, especially when the performance of the float solution is poor. More specifically, the update strategy of FCB estimation in a stand-alone receiver is proposed to realize the PPP-PAR. Thereafter, the solving process of FCB in a stand-alone receiver is summarized. Meanwhile, the influencing factors of the ambiguity success rate in the PPP-PAR without network corrections are analyzed. Meanwhile, the ambiguity residual constraint is added to adapt the particularity of the partial ambiguity-fixing without network corrections. Moreover, the positioning experiments with raw observation data at the Global Positioning System (GPS) globally distributed reference stations are conducted to determine the ambiguity residual threshold for post-processing and real-time scenarios. Finally, the positioning performance was verified by 22 GPS reference stations. The results show that convergence time is reduced by 15.8% and 26.4% in post-processing and real-time scenarios, respectively, when the float solution is unstable, compared with PPP using a float solution. However, if the float solution is stable, the PPP-PARC method has performance similar to the float solution. The method shows the significance of the PPP-PARC for future PPP applications in areas where network resource is deficient.

Dataset Information

Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance.

Publications

Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance.

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