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Chemical constituents of Chaenomeles sinensis twigs and their biological activity.


ABSTRACT: A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

SUBMITTER: Cha JM 

PROVIDER: S-EPMC7753107 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Chemical constituents of <i>Chaenomeles sinensis</i> twigs and their biological activity.

Cha Joon Min JM   Kim Dong Hyun DH   Subedi Lalita L   Khan Zahra Z   Choi Sang Un SU   Kim Sun Yeou SY   Kim Chung Sub CS  

Beilstein journal of organic chemistry 20201217


A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (<b>1</b>), was isolated from the twigs of <i>Chaenomeles sinensis</i> together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate <b>1</b> was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell li  ...[more]

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