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Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity.

ABSTRACT: Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

SUBMITTER: Lam SH 

PROVIDER: S-EPMC6222598 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity.

Lam Sio-Hong SH   Chen Po-Hsun PH   Hung Hsin-Yi HY   Hwang Tsong-Long TL   Chiang Chih-Chao CC   Thang Tran Dinh TD   Kuo Ping-Chung PC   Wu Tian-Shung TS  

Molecules (Basel, Switzerland) 20181005 10

Fifty-seven compounds were purified from the stems of <i>Tinospora sinensis</i>, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (<b>11</b>), and a benzenoid (1<b>7</b>), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition  ...[more]

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