Ontology highlight
ABSTRACT:
SUBMITTER: Gong X
PROVIDER: S-EPMC7754714 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Gong Xiaojian X Chen Xiaofang X Yu Dongmin D Zhang Nannan N Zhu Zhongliang Z Niu Liwen L Mao Yuxin Y Ge Honghua H
Journal of structural biology 20141025 3
Dephospho-CoA kinase (DPCK; EC 2.7.1.24) catalyzes the final step in the coenzyme A biosynthetic pathway. DPCK transfers a phosphate group from ATP to the 3-hydroxyl group of the ribose of dephosphocoenzyme A (dCoA) to yield CoA and ADP. Upon the binding of ligands, large conformational changes is induced in DPCKs, as well as in many other kinases, to shield the bound ATP in their catalytic site from the futile hydrolysis by bulk water molecules. To investigate the molecular mechanisms underlyin ...[more]