Ontology highlight
ABSTRACT:
SUBMITTER: van der Velden YU
PROVIDER: S-EPMC7755169 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
van der Velden Yme U YU Villaudy Julien J Siteur-van Rijnstra Esther E van der Linden Cynthia A CA Vink Monique A MA Schermer Edith E EE Weijer Kees K Berkhout Ben B Sanders Rogier W RW van Gils Marit J MJ
mAbs 20200101 1
Recent studies have shown the potential of broadly neutralizing antibodies (bnAbs) for HIV-1 treatment. One of the candidate antibodies moving into clinical trials is the bnAb PGDM1400. Here, we studied the therapeutic potency and escape pathways of bnAb PGDM1400 during monovalent therapy in human immune system (HIS) mice using the BG505, REJO, MJ4 and AMC008 virus isolates. PGDM1400 administered during chronic infection caused a modest decrease in viral load in the first week of administration ...[more]