Ontology highlight
ABSTRACT:
SUBMITTER: Giannini M
PROVIDER: S-EPMC7755276 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Giannini Marta M Bayona-Feliu Aleix A Sproviero Daisy D Barroso Sonia I SI Cereda Cristina C Aguilera Andrés A
PLoS genetics 20201210 12
TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, in which 97% of patients are familial and sporadic cases associated with TDP-43 proteinopathies and conditions clearing TDP-43 from the nucleus, but we know little about the molecular basis of the disease. After sho ...[more]