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Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

ABSTRACT: We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis.

SUBMITTER: Xia C

PROVIDER: S-EPMC7756121 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures.

Xia Chuanyou C Olsen Thale Kristin TK Zirakzadeh A Ali AA Almamoun Radwa R Sjöholm Louise K LK Dahlström Jenny J Sjöberg Jan J Claesson Hans-Erik HE Johnsen John Inge JI Winqvist Ola O Xu Dawei D Ekström Tomas J TJ Björkholm Magnus M Strååt Klas K

Frontiers in oncology 20201209

We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other ...[more]

PMID: 33363029

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