Dataset Information

Simultaneous Multiple Resonance Frequency imaging (SMURF): Fat-water imaging using multi-band principles.

ABSTRACT:

Purpose

To develop a fat-water imaging method that allows reliable separation of the two tissues, uses established robust reconstruction methods, and requires only one single-echo acquisition.

Theory and methods

The proposed method uses spectrally selective dual-band excitation in combination with CAIPIRINHA to generate separate images of fat and water simultaneously. Spatially selective excitation without cross-contamination is made possible by the use of spatial-spectral pulses. Fat and water images can either be visualized separately, or the fat images can be corrected for chemical shift displacement and, in gradient echo imaging, for chemical shift-related phase discrepancy, and recombined with water images, generating fat-water images free of chemical shift effects. Gradient echo and turbo spin echo sequences were developed based on this Simultaneous Multiple Resonance Frequency imaging (SMURF) approach and their performance was assessed at 3Tesla in imaging of the knee, breasts, and abdomen.

Results

The proposed method generated well-separated fat and water images with minimal unaliasing artefacts or cross-excitation, evidenced by the near absence of water signal attributed to the fat image and vice versa. The separation achieved was similar to or better than that using separate acquisitions with water- and fat-saturation or Dixon methods. The recombined fat-water images provided similar image contrast to conventional images, but the chemical shift effects were eliminated.

Conclusion

Simultaneous Multiple Resonance Frequency imaging is a robust fat-water imaging technique that offers a solution to imaging of body regions with significant amounts of fat.

SUBMITTER: Bachrata B

PROVIDER: S-EPMC7756227 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Simultaneous Multiple Resonance Frequency imaging (SMURF): Fat-water imaging using multi-band principles.

Bachrata Beata B Strasser Bernhard B Bogner Wolfgang W Schmid Albrecht Ingo AI Korinek Radim R Krššák Martin M Trattnig Siegfried S Robinson Simon Daniel SD

Magnetic resonance in medicine 20200927 3

<h4>Purpose</h4>To develop a fat-water imaging method that allows reliable separation of the two tissues, uses established robust reconstruction methods, and requires only one single-echo acquisition.<h4>Theory and methods</h4>The proposed method uses spectrally selective dual-band excitation in combination with CAIPIRINHA to generate separate images of fat and water simultaneously. Spatially selective excitation without cross-contamination is made possible by the use of spatial-spectral pulses. ...[more]

PMID: 32981114

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Project description:PURPOSE:Cardiac magnetic resonance fingerprinting (cMRF) has been recently introduced to simultaneously provide T1 , T2 , and M0 maps. Here, we develop a 3-point Dixon-cMRF approach to enable simultaneous water specific T1 , T2 , and M0 mapping of the heart and fat fraction (FF) estimation in a single breath-hold scan. METHODS:Dixon-cMRF is achieved by combining cMRF with several innovations that were previously introduced for other applications, including a 3-echo GRE acquisition with golden angle radial readout and a high-dimensional low-rank tensor constrained reconstruction to recover the highly undersampled time series images for each echo. Water-fat separation of the Dixon-cMRF time series is performed to allow for water- and fat-specific T1 , T2 , and M0 estimation, whereas FF estimation is extracted from the M0 maps. Dixon-cMRF was evaluated in a standardized T1 -T2 phantom, in a water-fat phantom, and in healthy subjects in comparison to current clinical standards: MOLLI, SASHA, T2 -GRASE, and 6-point Dixon proton density FF (PDFF) mapping. RESULTS:Dixon-cMRF water T1 and T2 maps showed good agreement with reference T1 and T2 mapping techniques (R2 > 0.99 and maximum normalized RMSE ~5%) in a standardized phantom. Good agreement was also observed between Dixon-cMRF FF and reference PDFF (R2 > 0.99) and between Dixon-cMRF water T1 and T2 and water selective T1 and T2 maps (R2 > 0.99) in a water-fat phantom. In vivo Dixon-cMRF water T1 values were in good agreement with MOLLI and water T2 values were slightly underestimated when compared to T2 -GRASE. Average myocardium septal T1 values were 1129 ± 38 ms, 1026 ± 28 ms, and 1045 ± 32 ms for SASHA, MOLLI, and the proposed water Dixon-cMRF. Average T2 values were 51.7 ± 2.2 ms and 42.8 ± 2.6 ms for T2 -GRASE and water Dixon-cMRF, respectively. Dixon-cMRF FF maps showed good agreement with in vivo PDFF measurements (R2 > 0.98) and average FF in the septum was measured at 1.3%. CONCLUSION:The proposed Dixon-cMRF allows to simultaneously quantify myocardial water T1 , water T2 , and FF in a single breath-hold scan, enabling multi-parametric T1 , T2 , and fat characterization. Moreover, reduced T1 and T2 quantification bias caused by water-fat partial volume was demonstrated in phantom experiments.

Project description:BackgroundConventional 2D inversion recovery (IR) and phase sensitive inversion recovery (PSIR) late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) have been widely incorporated into routine CMR for the assessment of myocardial viability. However, reliable suppression of fat signal, and increased isotropic spatial resolution and volumetric coverage within a clinically feasible scan time remain a challenge. In order to address these challenges, this work proposes a highly efficient respiratory motion-corrected 3D whole-heart water/fat LGE imaging framework.MethodsAn accelerated IR-prepared 3D dual-echo acquisition and motion-corrected reconstruction framework for whole-heart water/fat LGE imaging was developed. The acquisition sequence includes 2D image navigators (iNAV), which are used to track the respiratory motion of the heart and enable 100% scan efficiency. Non-rigid motion information estimated from the 2D iNAVs and from the data itself is integrated into a high-dimensional patch-based undersampled reconstruction technique (HD-PROST), to produce high-resolution water/fat 3D LGE images. A cohort of 20 patients with known or suspected cardiovascular disease was scanned with the proposed 3D water/fat LGE approach. 3D water LGE images were compared to conventional breath-held 2D LGE images (2-chamber, 4-chamber and stack of short-axis views) in terms of image quality (1: full diagnostic to 4: non-diagnostic) and presence of LGE findings.ResultsImage quality was considered diagnostic in 18/20 datasets for both 2D and 3D LGE magnitude images, with comparable image quality scores (2D: 2.05?±?0.72, 3D: 1.88?±?0.90, p-value?=?0.62) and overall agreement in LGE findings. Acquisition time for isotropic high-resolution (1.3mm3) water/fat LGE images was 8.0?±?1.4?min (3-fold acceleration, 60-88 slices covering the whole heart), while 2D LGE images were acquired in 5.6?±?2.2?min (12-18 slices, including pauses between breath-holds) albeit with a lower spatial resolution (1.40-1.75?mm in-plane ×?8?mm slice thickness).ConclusionA novel framework for motion-corrected whole-heart 3D water/fat LGE imaging has been introduced. The method was validated in patients with known or suspected cardiovascular disease, showing good agreement with conventional breath-held 2D LGE imaging, but offering higher spatial resolution, improved volumetric coverage and good image quality from a free-breathing acquisition with 100% scan efficiency and predictable scan time.

Dataset Information

Simultaneous Multiple Resonance Frequency imaging (SMURF): Fat-water imaging using multi-band principles.

Purpose

Theory and methods

Results

Conclusion

Publications

Simultaneous Multiple Resonance Frequency imaging (SMURF): Fat-water imaging using multi-band principles.

Similar Datasets

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