Ontology highlight
ABSTRACT:
SUBMITTER: Vianney YM
PROVIDER: S-EPMC7756412 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Vianney Yoanes Maria YM Preckwinkel Pit P Mohr Swantje S Weisz Klaus K
Chemistry (Weinheim an der Bergstrasse, Germany) 20201116 70
A parallel quadruplex derived from the Myc promoter sequence was extended by a stem-loop duplex at either its 5'- or 3'-terminus to mimic a quadruplex-duplex (Q-D) junction as a potential genomic target. High-resolution structures of the hybrids demonstrate continuous stacking of the duplex on the quadruplex core without significant perturbations. An indoloquinoline ligand carrying an aminoalkyl side chain was shown to bind the Q-D hybrids with a very high affinity in the order K<sub>a</sub> ≈10 ...[more]