Ontology highlight
ABSTRACT:
SUBMITTER: Schawalder L
PROVIDER: S-EPMC7756751 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Schawalder Lara L Hönger Gideon G Kleiser Marc M van Heck Michelle R MR van de Pasch Loes A L LAL Vendelbosch Sanne S Rozemuller Erik H EH Schaub Stefan S
HLA 20201028 1
Eplets are defined as distinct amino acid configurations on the surface of HLA molecules. The aim of this study was to estimate the immunogenicity of HLA-DQ eplets in a cohort of 221 pregnancies with HLA-DQ mismatches. We defined the immunogenicity of an eplet by the frequency of antibody responses against it. Around 90% of all listed DQB1 or DQA1 eplets were at least five times mismatched and thus included for the calculation of their immunogenicity. The DQB1 eplets with the five highest immuno ...[more]