Ontology highlight
ABSTRACT:
SUBMITTER: Allaway KC
PROVIDER: S-EPMC7758062 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Allaway Kathryn C KC Muñoz William W Tremblay Robin R Sherer Mia M Herron Jacob J Rudy Bernardo B Machold Robert R Fishell Gordon G
eLife 20201223
The basal forebrain cholinergic system projects broadly throughout the cortex and constitutes a critical source of neuromodulation for arousal and attention. Traditionally, this system was thought to function diffusely. However, recent studies have revealed a high degree of spatiotemporal specificity in cholinergic signaling. How the organization of cholinergic afferents confers this level of precision remains unknown. Here, using intersectional genetic fate mapping, we demonstrate that choliner ...[more]