Ontology highlight
ABSTRACT:
SUBMITTER: Kiriakidi S
PROVIDER: S-EPMC7758360 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Kiriakidi Sofia S Chatzigiannis Christos C Papaemmanouil Christina C Tzakos Andreas G AG Cournia Zoe Z Mavromoustakos Thomas T
Computational and structural biotechnology journal 20201203
Hypertension, mediated by the Angiotensin II receptor type 1 (AT1R), is still the major cause of premature death despite the discovery of novel therapeutics, highlighting the importance of an in depth understanding of the drug-AT1R recognition mechanisms coupled with the impact of the membrane environment on the interaction of drugs with AT1R. Herein, we examine the interplay of cholesterol-lipid-candesartan and the AT1R using Molecular Dynamics simulations of a model membrane consisting of 60:4 ...[more]