Ontology highlight
ABSTRACT:
SUBMITTER: Lai CH
PROVIDER: S-EPMC3675143 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lai Chih-Ho CH Lai Cheng-Kuo CK Lin Ying-Ju YJ Hung Chiu-Lien CL Chu Chia-Han CH Feng Chun-Lung CL Chang Chia-Shuo CS Su Hong-Lin HL
PloS one 20130606 6
Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed by CdtA, CdtB, and CdtC. Among these toxin subunits, CdtA and CdtC function as essential proteins that mediate toxin binding to cytoplasmic membranes followed by delivery of CdtB into the nucleus. The binding of CdtA/CdtC to the cell surface is mediated by cholesterol, a major component in lipid rafts. Although the putative cholesterol recognition/interaction amino acid consensus (CRAC) d ...[more]