Ontology highlight
ABSTRACT:
SUBMITTER: Sevvana M
PROVIDER: S-EPMC7760643 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Sevvana Madhumati M Rogers Thomas F TF Miller Andrew S AS Long Feng F Klose Thomas T Beutler Nathan N Lai Yen-Chung YC Parren Mara M Walker Laura M LM Buda Geeta G Burton Dennis R DR Rossmann Michael G MG Kuhn Richard J RJ
Viruses 20201124 12
Zika virus (ZIKV), a mosquito-borne human flavivirus that causes microcephaly and other neurological disorders, has been a recent focus for the development of flavivirus vaccines and therapeutics. We report here a 4.0 Å resolution structure of the mature ZIKV in complex with ADI-30056, a ZIKV-specific human monoclonal antibody (hMAb) isolated from a ZIKV infected donor with a prior dengue virus infection. The structure shows that the hMAb interactions span across the E protein dimers on the viru ...[more]