Ontology highlight
ABSTRACT:
SUBMITTER: Hlavac V
PROVIDER: S-EPMC7760784 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Hlavac Viktor V Mohelnikova-Duchonova Beatrice B Lovecek Martin M Ehrmann Jiri J Brynychova Veronika V Kolarova Katerina K Soucek Pavel P
Genes 20201124 12
Mutation spectra of 250 cancer driver, druggable, and actionable genes were analyzed in surgically resected pancreatic ductal adenocarcinoma (PDAC) patients who developed metachronous pulmonary metastases. Targeted sequencing was performed in DNA from blood and archival samples of 15 primary tumors and three paired metastases. Results were complemented with the determination of G12V mutation in <i>KRAS</i> by droplet digital PCR. The median number of protein-changing mutations was 52 per patient ...[more]