Migrating Lung Monocytes Internalize and Inhibit Growth of Aspergillus fumigatus Conidia.
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SUBMITTER: Schiefermeier-Mach N
PROVIDER: S-EPMC7760852 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
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Migrating Lung Monocytes Internalize and Inhibit Growth of <i>Aspergillus fumigatus</i> Conidia.
Schiefermeier-Mach Natalia N Haller Thomas T Geley Stephan S Perkhofer Susanne S
Pathogens (Basel, Switzerland) 20201124 12
Monocytes are important players to combat the ubiquitously present fungus <i>Aspergillus fumigatus.</i> Recruitment of monocytes to sites of fungal <i>A. fumigatus</i> infection has been shown in vivo. Upon exposure to <i>A. fumigatus</i> in vitro, purified murine and human blood monocytes secrete inflammatory cytokines and fungicidal mediators. Mononuclear tissue phagocytes are phenotypically and functionally different from those circulating in the blood and their role in antifungal defenses is ...[more]
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