Ontology highlight
ABSTRACT:
SUBMITTER: Khoury JD
PROVIDER: S-EPMC7761301 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Khoury Joseph D JD Tashakori Mehrnoosh M Yang Hong H Loghavi Sanam S Wang Ying Y Wang Jing J Piya Sujan S Borthakur Gautam G
Cancers 20201125 12
RAF molecules play a critical role in cell signaling through their integral impact on the RAS/RAF/MEK/ERK signaling pathway, which is constitutively activated in a sizeable subset of acute myeloid leukemia (AML) patients. We evaluated the impact of pan-RAF inhibition using LY3009120 in AML cells harboring mutations upstream and downstream of RAF. LY3009120 had anti-proliferative and pro-apoptotic effects and suppressed pERK1/2 levels in leukemic cells with <i>RAS</i> and <i>FLT3</i> mutations. U ...[more]