Ontology highlight
ABSTRACT:
SUBMITTER: Plum S
PROVIDER: S-EPMC7761546 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Plum Sarah S Eggers Britta B Helling Stefan S Stepath Markus M Theiss Carsten C Leite Renata E P REP Molina Mariana M Grinberg Lea T LT Riederer Peter P Gerlach Manfred M May Caroline C Marcus Katrin K
Cells 20201202 12
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlying the alteration of synaptic function in PD, a proteomic study was performed. Therefore, synaptosomes were isolated by density gradient centrifugation from SNpc tissue of individua ...[more]