Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Neuron
DISEASE(S): Parkinson's Disease
SUBMITTER: Britta Eggers
LAB HEAD: Prof. Dr. Katrin Marcus
PROVIDER: PXD022092 | Pride | 2021-06-07
REPOSITORIES: Pride
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Annotation.xlsx | Xlsx | |||
F065935.dat | Other | |||
F065935.mzid.gz | Mzid | |||
F065936.dat | Other | |||
F065936.mzid.gz | Mzid |
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Cells 20201202 12
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes underlying the alteration of synaptic function in PD, a proteomic study was performed. Therefore, synaptosomes were isolated by density gradient centrifugation from SNpc tissue of individua ...[more]