Reply to Comments on Proteomic Investigations of Two Pakistani Naja Snake Venom Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles. Toxins 2020, 12, 669.
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ABSTRACT:
SUBMITTER: Munawar A
PROVIDER: S-EPMC7762587 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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Reply to Comments on Proteomic Investigations of Two Pakistani <i>Naja</i> Snake Venom Species Unravel the Venom Complexity, Posttranslational Modifications, and Presence of Extracellular Vesicles. <i>Toxins</i> 2020, <i>12</i>, 669.
Munawar Aisha A Dreyer Benjamin B Schlüter Hartmut H Betzel Christian C
Toxins 20201208 12
We appreciate the commentary on our article, and we would like to take the opportunity to address several points raised in the reviewers' commentary [...]. ...[more]
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Project description:Latest advancement of omics technologies allows in-depth characterization of venom compositions. In the present work we present a proteomic study of two snake venoms of the genus Naja i.e. Naja naja (black cobra) and Naja oxiana (brown cobra), of Pakistani origin. The present study has shown that these snake venoms consist of a highly diversified proteome. Furthermore, the data also revealed variation among closely related species. High throughput mass spectrometric analysis of the venom proteome allowed to identify for the N. naja venom 34 protein families and for the N. oxiana 24 protein families. The comparative evaluation of the two venoms showed that N. naja consists of a more complex venom proteome than N. oxiana venom.
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