Ontology highlight
ABSTRACT:
SUBMITTER: Makhaeva GF
PROVIDER: S-EPMC7763995 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Makhaeva Galina F GF Kovaleva Nadezhda V NV Rudakova Elena V EV Boltneva Natalia P NP Lushchekina Sofya V SV Faingold Irina I II Poletaeva Darya A DA Soldatova Yuliya V YV Kotelnikova Raisa A RA Serkov Igor V IV Ustinov Anatoly K AK Proshin Alexey N AN Radchenko Eugene V EV Palyulin Vladimir A VA Richardson Rudy J RJ
Molecules (Basel, Switzerland) 20201212 24
New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (<b>7</b>) or aminoalkyl (<b>8</b>) spacers were synthesized as potential multifunctional agents for Alzheimer's disease (AD) treatment. All compounds were potent inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with selectivity toward BChE. Lead compound <b>8c</b>, 2,6-di-<i>tert</i>-butyl-4-{[2-(7,8,9,10- tetrahydro-6H-c ...[more]