Ontology highlight
ABSTRACT:
SUBMITTER: Morell A
PROVIDER: S-EPMC7764606 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Morell Anselm A Čermáková Lucie L Novotná Eva E Laštovičková Lenka L Haddad Melodie M Haddad Andrew A Portillo Ramon R Wsól Vladimír V
Cancers 20201211 12
Over the last few years, aldo-keto reductase family 1 member C3 (AKR1C3) has been associated with the emergence of multidrug resistance (MDR), thereby hindering chemotherapy against cancer. In particular, impaired efficacy of the gold standards of induction therapy in acute myeloid leukaemia (AML) has been correlated with AKR1C3 expression, as this enzyme metabolises several drugs including anthracyclines. Therefore, the development of selective AKR1C3 inhibitors may help to overcome chemoresist ...[more]